semaglutide hepatic impairment child-pugh 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled phase 2 trial AISF practice guidance on pharmacological

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Cosmos Study October 14, 2025 Dual-Team Study Team A:Kersten Bartelt, RNEric Barkley Team B:Joel Jones, PharmDJoe Deckert, PhD Key Findings Among non-diabetic patients without chronic kidney disease (CKD), there was a minimal increase of 0.01 mg/dL to 0.02 mg/dL in serum creatinine in the months following initiation of semaglutide, liraglutide, or tirzepatide

The same research group also found that GLP-1 RA therapy significantly increased TT, fT, SHBG, and gonadotropin levels, with concurrent improvements in erectile function

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Cell Metab 2013;17:81937